Cavaliers vs 76ers Prediction and Preview: NBA, Oct 22

Cavaliers at 76ers, Thursday, October 22: tip is 7:00 PM ET in Philadelphia. The 76ers picked up a nice road win over the Knicks in their regular season opener and now do battle with James Harden, Donovan Mitchell and company.

• Price: 76ers 59¢, Cavaliers 41¢ (Polymarket, as of Thu 6:27 AM ET)

• Kalshi: 76ers 58¢, Cavaliers 42¢

• Game total: 236.5 points (over 49¢, under 52¢)

• 2027 title price: Cavaliers 3¢, 76ers 11¢ (Polymarket US)

• Live price and every move: NBA WIRE

Who is favored in Cavaliers vs 76ers

Polymarket has the 76ers at 59¢ and the Cavaliers at 41¢. Kalshi has the 76ers 1¢ cheaper at 58¢. Both apps sit side by side on NBA MARKET. This season, the team favored at tip has won 10 of 14 games we have logged (71%).

More NBA previews are up for tonight’s other games, and today’s board has every game across the four sports.

The rotations, by last season’s numbers

Last season’s regular-season numbers on this season’s rosters. Usage is the share of team possessions a player finished while on the floor.

Cavaliers

• Donovan Mitchell: 33.5 min, 32.2% usage, 27.9 pts, 4.5 reb, 5.7 ast

• James Harden: 33.8 min, 24.0% usage, 20.5 pts, 4.8 reb, 7.7 ast

• Evan Mobley: 31.9 min, 22.5% usage, 18.2 pts, 9.0 reb, 3.6 ast

• Peyton Watson: 29.6 min, 20.6% usage, 14.6 pts, 4.9 reb, 2.1 ast (new, was DEN)

• Jarrett Allen: 27.1 min, 19.9% usage, 15.4 pts, 8.5 reb, 1.8 ast

76ers

• Jaylen Brown: 34.4 min, 36.2% usage, 28.7 pts, 6.9 reb, 5.1 ast (new, was BOS)

• Tyrese Maxey: 38.0 min, 29.4% usage, 28.3 pts, 4.1 reb, 6.6 ast

• Joel Embiid: 31.6 min, 33.5% usage, 26.9 pts, 7.7 reb, 3.9 ast

• LeBron James: 33.2 min, 27.2% usage, 20.9 pts, 6.1 reb, 7.2 ast (new, was LAL)

• VJ Edgecombe: 35.0 min, 20.1% usage, 16.0 pts, 5.6 reb, 4.2 ast

What to watch

• Mitchell drives the Cavaliers. 32.2% usage in 33.5 minutes last season; Harden is next at 24.0%.

• Brown is new and one of the 76ers’ top options. 36.2% usage in 34.4 minutes with BOS last season; Embiid is next at 33.5%. Don’t forget about LeBron either! This team is stacked.

• 76ers’ usage does not add up. Brown (36.2%), Embiid (33.5%), Maxey (29.4%), James (27.2%) used a combined 126% of their teams’ possessions last season.

Cavaliers vs 76ers FAQ

Is Donovan Mitchell playing tonight?

Donovan Mitchell was not on the injury report as of Thu 6:27 AM ET.

Who is favored in Cavaliers vs 76ers?

The 76ers. Polymarket has them at 59¢, which reads as about a 59% chance, and the price moves live on NBA WIRE.

When and where is Cavaliers vs 76ers?

Thursday, October 22, at 7:00 PM ET, in Philadelphia.

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